P53 plays a major role in the cellular response to DNA damage and other genomic aberrations. The activation of p53 can lead to either cell cycle arrest and DNA repair, or apoptosis. p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro. p53 can apparently be phosphorylated by ATM, ATR, and DNAPK at Ser15; the phosphorylation impairs the ability of MDM2 to bind p53, promoting both the accumulation and functional activation of p53 in response to DNA damage. Chk2 and Chk1 can phosphorylate p53 at Ser20, enhancing its tetramerization, stability and activity. p53 is phosphorylated at Ser392 in vivo and by CAK in vitro. Phosphorylation of p53 at Ser392 is altered in human tumors and has been reported to influence the growth suppressor function, DNA binding and transcriptional activation of p53.
p53广泛的研究发现P53肿瘤抑制基因对50%以上的人类癌症具有抑制突变的功能。P53蛋白水平在正常细胞中表达低，在DNA突变时或各种各样细胞遇难信号时反应增加。该基因突变或缺失是导致许多肿瘤发生的原因。P53同时也是细胞凋亡的调控因子。此抗体可用于P53肿瘤抑制基因功能的研究。
我公司新研发的P53(p53细胞肿瘤抗原)抗体以及配对磷酸化p53 (phospho S371)抗体已经通过检验测试已经通过检验测试，可以应用于蛋白印迹（WB），免疫组化（IHC），免疫细胞化学（ICC），酶联免疫吸附试验（ELISA），免疫沉淀（IP），免疫荧光（IF）实验。具体信息如下：
编号 产品名称
PR-1005， P53 Antibody
PR-1005P， p53 (phospho S371) Antibody
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镇江厚普生物科技有限公司销售部
2015-10-28