Background:  Structurally, C-C or b-chemokines are characterized by a set of conserved, adjacent cysteines. Members of this family include MCP-1, MCP-2, MCP-3, MIP-1α, MIP-1β, RANTES and I-309. RANTES (regulated upon activation, normal T cell expressed and secreted) is expressed by platelets, eosinophils, fibroblasts, macrophages, endothelial cells and T lymphocytes. Consistent with its belonging to the chemokine family, RANTES exhibits strong chemoattractant activity towards monocytes and NK cells. I-309 was initially identified as a factor present in g/d T lymphocytes. I-309 cDNA encodes a protein 73 amino acids in length with one potential N-linked glycosylation site Unlike the other members of the C-C family, I-309 does not induce chemotaxis in natural killer (NK) cells.

Description: Rabbit polyclonal to CCL1

Immunogen: KLH conjugated synthetic peptide derived from CCL1

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 11 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.