Background:  CNK2 (connector enhancer of kinase suppressor of Ras 2), also known as KSR2 or CNKSR2, is a 1,034 amino acid cytoplasmic and peripheral membrane protein involved in the RAS-dependent signaling pathway. RAS is essential for integrating and transmitting proliferation, differentiation and survival signals elicited by membrane receptors to downstream effector pathways. RAF is part of the RAS-dependent signaling pathway and is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. A member of the CNKSR family, CNK2 contains one CRIC domain, a SAM (sterile alpha motif) domain, one PH domain, a PZD domain and a single DUF1170 domain. CNK2 exists as two alternatively spliced isoforms that undergo post-translational phosphorylation.

Description: Rabbit polyclonal to CNKSR2

Immunogen: KLH conjugated synthetic peptide derived from CNKSR2

Specificity:  ·Reacts with Human, Mouse, Pig, Dog and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 118 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.