Background:  OGFOD2 (2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2) is a 350 amino acid protein that contains one PKHD (prolyl/lysyl hydroxylase) domain and is able to bind both ascorbate and iron as cofactors. It is suspected that members of the 2-oxoglutarate oxygenase protein family function to catalyze reactions that involve reactive oxidizing species, such as hydroxylations, desaturations and oxidative ring closures. There are four isoforms of OGFOD2 that are produced as a result of alternative splicing events. The gene encoding OGFOD2 maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and trisomy 12p, which causes facial developmental defects and seizure disorders.

Description: Rabbit polyclonal to OGFOD2

Immunogen: KLH conjugated synthetic peptide derived from OGFOD2

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 39 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.