Background:  CDK2AP1 (cyclin-dependent kinase 2 associated protein 1), also designated p12 and DOC-1, is a growth suppressor that binds to and inhibits DNA pol å/primase. When bound, CDK2AP1 affects the initiation step, but not the elongation phase, of replication. CDK2AP1 also binds to cyclin-dependent kinase 2 (Cdk2) and targets it for proteolysis. CDK2AP1 promotes cell cycle arrest by regulating the S phase of the cycle, and may trigger apoptosis. The growth factor TGF∫1 transcriptionally-induces CDK2AP1 expression, which, in turn, mediates the growth inhibitory activity of TGF∫1 by modulating Cdk2 activities and pRB phosphorylation. Due to its ability to trigger apoptosis, CDK2AP1 is thought to function as a tumor suppressor. CDK2AP2 (cyclin-dependent kinase 2 associated protein 2), also known as p14 or DOC-1R, is a 126 amino acid ubiquitously expressed protein that interacts with CDK2AP1 and may play a role in growth and tumor suppression.

Description: Rabbit polyclonal to CDK2AP2

Immunogen: KLH conjugated synthetic peptide derived from CDK2AP2

Specificity:  ·Reacts with Human, Mouse, Pig, Dog and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 13 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.