Background:  Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations of ankyrin genes lead to severe genetic diseases, such as fatal cardiac arrhythmias and hereditary spherocytosis. ANKRD40 (ankyrin repeat domain 40) is a 368 amino acid protein that contains 2 ANK repeats. Conserved in chimpanzee, canine, bovine, mouse, rat, chicken and zebrafish, ANKRD40 may play a role in cell adhesion and migration. ANKRD40 is encoded by a gene that maps to human chromosome 17q21.33. Chromosome 17 makes up over 2.5% of the human genome and contains about 81 million bases, which encode over 1,200 genes. Chromosome 17 is linked to neurofibromatosis, a condition characterized by neural and epidermal lesions and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.

Description: Rabbit polyclonal to ANKRD40

Immunogen: KLH conjugated synthetic peptide derived from ANKRD40

Specificity:  ·Reacts with Human, Mouse, Pig, Dog and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 41 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.