Background:  Cutaneous T cell lymphomas (CTCL) represent a group of malignancies that originate from CD4-T lymphocytes and manifest on the skin. CTCL is a general term for several neoplasms including mycosis fungoides, T cell leukemia/lymphoma and pagetoid reticulosis, all of which are very difficult to treat in the advanced stages. CTAGE4 (cutaneous T cell lymphoma associated-antigen 4) , CTAGE6 and CTAGE9 are all 1777 amino acid single-pass membrane proteins that belong to the CTAGE family. All three proteins are found in CTCLs and are encoded by genes that map to human chromosome 7. Chromosome 7 houses over 1,000 genes, comprises nearly 5% of the human genome and has been linked to osteogenesis imperfecta, Pendred syndrome, lissencephaly, citrulline-mia and Shwachman-Diamond syndrome.

Description: Rabbit polyclonal to CTAGE6

Immunogen: KLH conjugated synthetic peptide derived from CTAGE6

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 88 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.