Background:  NPC2 is a secreted protein mapping against gene 14q24.3. NPC2 regulates the lipid composition of sperm membranes during maturation in the epididymis. Mutations in the NPC2 gene may cause Nieman-Pick type C2 disease and frontal lobe atrophy. Nieman-Pick type C2 is a fatal hereditary disease characterized by defective lysosome release of cholesterol. The disease is caused by HE1 deficiency, a lysosmal protein proven to be undetectable in fibroblasts from NPC2 patients. This differentiates NPC2 from NPC1, as NPC1 has HE1 protein present.

Description: Rabbit polyclonal to NPC2

Immunogen: KLH conjugated synthetic peptide derived from NPC2

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 16 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.