Background:  COBLL1 (Cordon-bleu protein-like 1), also known as COBLR1 or COBL-like 1, is a 1,204 amino acid protein expressed in liver, kidney, pancreas, spinal cord, brain, lung and ovary. The mouse and human COBLL1 proteins share 63% identity. COBLL1 is highly related to Cordon-bleu, a protein involved in midline development that is specifically expressed in the node and its derivatives, including a portion of the neural tube floor plate, the notochord and the dorsal foregut. Both Cordon-bleu and COBLL1 contain a conserved N-terminus with KRAP (lysine, arginine and proline-rich) repeats, a homologous C-terminus with at least one WH2 domain (one in COBLL1 and three in Cordon-bleu) and a divergent central region. Due to the high degree of similarity between COBLL1 and Cordon-bleu, it has been suggested that COBLL1 may functionally compensate for Cordon-bleu in its absence.

Description: Rabbit polyclonal to COBLL1

Immunogen: KLH conjugated synthetic peptide derived from COBLL1

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 132 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.