Background:  CEP152, also known as centrosomal protein of 152 kDa, MCPH4 or SCKL5, is a 1,654 amino acid protein that is required for centrosome duplication. CEP152 is responsible for regulating genomic integrity as well as initiating ATR-mediated checkpoint signaling in response to DNA damage. CEP152 interacts with Sak and CENPJ, which are important for centriole formation as well as the cylin dependent kinase 2-interacting protein (CINP). Defects in CEP152 leads to Seckel syndrome type 5 (SCKL5) and microcephaly primary type 4 (MCPH4), both of which are congenital diseases and cause mental retardation. CEP152 exists as three different alternatively spliced isoforms and is post-translationally phosphorylated at amino acid residue 1258 (tyrosine) and 1405 (serine). The gene encoding CEP152 maps to human chromosome 15.

Description: Rabbit polyclonal to CEP152

Immunogen: KLH conjugated synthetic peptide derived from CEP152

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 189 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.