Background:  The GTPase of the immunity-associated protein (GIMAP) family of proteins include seven members that are expressed by genes residing on human chromosome 7. GIMAP proteins have been implicated in the regulation of lymphomyeloid cell survival. GIMAP6 (GTPase, IMAP family member 6), also known as IAN6 (immunity-associated nucleotide 6) or IAN2 (immunity-associated nucleotide 2), is a 292 amino acid protein that exists as two alternatively spliced isoforms. Highly expressed in placenta, lung, spleen and lymph node, GIMAP6 is found at moderate levels in heart, kidney, digestive tract and thymus. The gene encoding GIMPA6 maps to human chromosome 7, which houses over 1,000 genes, comprises nearly 5% of the human genome and has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. Highly expressed in spleen, lymph nodes, lung and placenta. Expressed at moderate level in thymus, kidney, heart and digestive tract. Weakly expressed in other lymphoid tissues.

Description: Rabbit polyclonal to GIMAP6

Immunogen: KLH conjugated synthetic peptide derived from GIMAP6

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 33 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.