Background:  FERM domains are roughly 150 amino acids in length and are found in a number of cytoskeletal-associated proteins such as ezrin, radixin, moesin and 4.1 (erythrocyte membrane protein band 4.1), where they provide a link between cytoskeletal signals and membrane dynamics. FRMD1 (FERM domain-containing protein 1) is a 549 amino acid protein containing one FERM domain. The gene encoding FRMD1 maps to human chromosome 6q27. Making up nearly 6% of the human genome, chromosome 6 contains around 1,200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. A bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6.

Description: Rabbit polyclonal to FRMD1

Immunogen: KLH conjugated synthetic peptide derived from FRMD1

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 63 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.