Background:  GPCR TGR7 is a G protein-coupled receptor specifically responsive to beta-alanina. It localizes at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanina. GPCR TGR7 may regulate nociceptor function and/or development, including the sensation or modulation of pain. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).

Description: Rabbit polyclonal to GPCR TGR7

Immunogen: KLH conjugated synthetic peptide derived from GPCR TGR7

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 36 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry: 1/100;

·Immunofluorescence: 1/50-200;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.