Background:  Filamins are Actin-binding proteins which contain an N-terminal Actin-binding domain, a membrane glycoprotein domain and a C-terminal self-association domain. Filamins help reshape the cytoskeleton by forming flexible cross-links between two Actin filaments, which maintain membrane integrity during force application. Filamins also participate in signal transduction pathways associated with cell motility, adhesion, differentiation and survival, and force transduction. The filamin family is comprised of Filamin 1, Filamin 2 and Filamin 3. Filamin 3, also designated Filamin B and beta-Filamin, is a form of Filamin that plays a role in endochondral ossification, vertebral segmentation and joint formation. The interaction of Filamin 3 with Filamin 1 may allow neuroblast migration into the cortical plate from the ventricular zone. Muta-tions in the gene that encodes for Filamin 3, FLNB, are associated with five human skeletal disorders, specifically, autosomal dominant Larsen syndrome, spondylocarpotarsal syndrome, type I atelosteogenesis, type III atelosteogenesis and Boomerang dysplasia as well as the neurologic disorder peri-ventricular heterotopia.

Description: Rabbit polyclonal to Filamin 3

Immunogen: KLH conjugated synthetic peptide derived from Filamin 3

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry: 1/100;

·Immunofluorescence: 1/50-200;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.