Background: NIPBL (Nipped-B-like protein), also known as IDN3, Delangin or CDLS, is a 2,804 amino acid nuclear protein that is the mammalian homolog of the Drosophila Nipped-B gene product, a protein that plays a role in developmental regulation by facilitating the communication between promoters and transcriptional enhancers. Widely expressed with particularly high levels present in skeletal muscle, heart, liver and kidney, NIPBL contains five HEAT repeats and interacts with HP1å, possibly playing a role in sister chromatid adhesion and in the maintenance of proper chromatin structure. NIPBL exists as three isoforms and is subject to DNA damage-dependent phosphorylation, probably by ATM or ATR. Mutations in the gene encoding NIPBL are the cause of Cornelia de Lange syndrome type 1 (CDLS1), a developmental disorder that is characterized by facial dysmorphisms, abnormal hands and feet, growth delay, cognitive retardation and various other malformations, including gastroesophageal dysfunction and cardiac, ophthalmologic and genitourinary anomalies.

Description: Rabbit polyclonal to IDN3

Immunogen: KLH conjugated synthetic peptide derived from IDN3

Specificity:  ·Reacts with Human, Mouse, Pig, Dog and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 304 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.