Background: ABI2 (Abelson interactor 2) belongs to the ABI family. The Abelson interactors are among a group of proteins that interact with Abl tyrosine kinase, a non-receptor tyrosine kinase whose activation results in the regulation of cytoskeleton function, cell growth and apoptosis in response to a variety of biological stimuli. ABI2 may act in regulation of cell growth and transformation by interacting tyrosine kinases ABL1 and/or ABL2 and may be involved in cytoskeletal reorganization and regulation of the ABL1/c-Abl-mediated phosphorylation of MENA. ABI2 is also known to be a tumor suppressor and a cell migration inhibitor.

Description: Rabbit polyclonal to ABI2

Immunogen: KLH conjugated synthetic peptide derived from ABI2

Specificity:  ·Reacts with Human, Mouse, Pig, Dog and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 56 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.