会员登陆 / 下载中心
当前位置:产品目录 > 抗体 >> 多克隆抗体
Bcl-2 alpha antibody, Bcl2 alpha蛋白抗体

 
编 号 PR-7872
产品名称 Bcl-2 alpha antibody, Bcl2 alpha蛋白抗体
规 格 0.2ml
价 格 1980元
应 用 IHC,WB,ELISA,ICC,IP,IF
品 牌 Hopebiot

详细信息: 说明书下载

Background:  BCL2 is an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants (alpha and beta) produced by alternate splicing, differ in their C-terminal ends. BCL2 suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. It regulates cell death by controlling the mitochondrial membrane permeability. It appears to function in a feedback loop system with caspases. BCL2 inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF1). It can form homodimers, and heterodimers with BAX, BAD, BAK and BclX(L). Heterodimerization with BAX requires intact BH1 and BH2 domains, and is necessary for anti-apoptotic activity. Also interacts with APAF1, RAF1, TP53BP2, BBC3, BCL2L1 and BNIPL.

Description: Rabbit polyclonal to Bcl-2 alpha

Immunogen: KLH conjugated synthetic peptide derived from Bcl-2 alpha

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 26 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.

相关同类产品:

网站首页 | 公司动态 | 产品中心 | 定制服务 | 代理产品 | 技术专栏 | 客户留言 | 联系我们

Copyright @ 2011 All Rights Reserved 江苏镇江厚普生物科技有限公司 备案/许可证编号为:苏ICP备11043267号

地址:江苏省丹阳市吕城工业园 邮编:212300 电子邮箱:hopebiotech@163.com

订货电话:0511-86909515 传真:0511-86909515 访问量:21572215