Background:  The Factor H gene family is a multidomain, multifunctional protein family whose individual members are defined by conserved structural elements, which display diverse yet often overlapping functions. These proteins share a common structural motif, the short consensus repeat (SCR), which is structurally conserved among related genes and between phylogenetically divergent species. SCR domains typically exist in a wide variety of complement and adhesion proteins. FHR-4 (Complement factor H-related protein 4) is a secreted protein that functions as a homodimer and contains five SCR domains. The dimeric form of FHR-4 is present in triglyceride-rich lipoproteins and may play a role in lipid metabolism. Unlike FHR-3, FHR-4 does not bind heparin, however both FHR-3 and FHR-4 enhance the cofactor activity of factor H in complement 3b (C3b) inactivation.

Description: Rabbit polyclonal to CFHL4

Immunogen: KLH conjugated synthetic peptide derived from CFHL4

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 63 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.