Background:  PCMTD1 (protein-L-isoaspartate O-methyltransferase domain-containing protein 1) is a 357 amino acid cytoplasmic protein that is a member of the L-isoaspartyl/D-aspartyl protein methyltransferase family. Members of this family participate in the degradation and/or repair of damaged proteins by specifically recognizing isomerized Asp or Asn residues in peptides and proteins. PCMTD1 is related to PCMT1, which catalyzes the conversion of abnormal L-isoaspartyl and D-aspartyl residues to methyl esters that may then spontaneously hydrolyze to re-form normal aspartyl residues. In mice lacking PCMT1, damaged proteins accumulate in a variety of tissues and the phenotypic result is progressive epilepsy and death at an early age. There are two isoforms of PCMTD1 that are produced as a result of alternative splicing events.

 Description: Rabbit polyclonal to PCMTD1

Immunogen: KLH conjugated synthetic peptide derived from PCMTD1

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 41 kDa;

·Immunohistochemistry (Frozen/paraffin tissue section): 1/50-200;

·Immunocytochemistry: 1/100;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.