Background:  Bcl-8 (B-cell CLL/lymphoma 8) is a 100 amino acid protein that is expressed in prostate and testis. The Bcl-8 family provides examples of both types of segmental duplication: interchromosomal and intrachromosomal. A chromosomal aberration involving Bcl-8 exists in diffuse large cell lymphoma (DLCL). The Bcl-8/IgH translocation leaves the coding region of Bcl-8 intact, but may have pathogenic effects due to alterations in the expression level of Bcl-8. The Bcl-8 gene is not normally expressed in lymphoid tissues, but its expression can be activated by chromosomal translocation or by other mechanisms in DLCL.

Description: Rabbit polyclonal to BCL8

Immunogen: KLH conjugated synthetic peptide derived from BCL8

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 330 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.