Background:  Pirh2, also known as Androgen receptor N-terminal-interacting protein(ARNIP), ZFP363 or CHIMP. It binds to p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. This gene is oncogenic as the loss of p53 function contributes to malignant tumor development. Pirh2 expression decreases the level of p53 and a decrease of endogenous Pirh2 expression ups p53 levels. Pirh2 is therefore considered, together with MDM2, to be acting as a negative regulator of p53 function.

Description: Rabbit polyclonal to Pirh2

Immunogen: KLH conjugated synthetic peptide derived from Pirh2

Specificity:  ·Reacts with Human, Mouse, Pig and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 30 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;

·Immunocytochemistry: 1/100-200;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.