Background:  This member of the Ser/Thr protein kinase family (IkappaB kinase subfamily) phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. It is highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas, placenta, and may play a special role in the immune response; it is weakly expressed in lung, kidney, prostate, ovary and colon. IKKi/IKKe is also overexpressed in breast cancers.

Description: Rabbit polyclonal to IKBKE

Immunogen: KLH conjugated synthetic peptide derived from IKBKE

Specificity:  ·Reacts with Human, Mouse and Rat

.·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 80 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;

·Immunocytochemistry: 1/100-200;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.