Background:  Elongation of very long chain fatty acid-like (ELOVL) proteins 1-6 are members of the ELO family of proteins, which play an important role in tissue-specific biosynthesis of very long chain fatty acids and sphingolipids. The ELOVL proteins act as catalysts in fatty acid elongation reduction and localize to the endoplasmic reticulum (ER). Elongation of very long chain fatty acids-like 4 (ELOVL4) is expressed in ER in the retina and, to a lesser extent, in the brain. ELOVL4 is a possible photoreceptor-specific component of the fatty acid elongation system residing on the ER. Mutations in the ELOVL4 gene cause autosomal dominant Stargardt disease 3 (STGD3) and autosomal dominant Stargardt-like macular dystrophy (ADMD). STGD3 is a form of macular degeneration that causes macular atrophy, decreased visual acuity and extensive fundus flecks in affected individuals.

Description: Rabbit polyclonal to ELOVL4

Immunogen: KLH conjugated synthetic peptide derived from ELOVL4

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 37 kDa;

·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-200;

·Immunocytochemistry: 1/100;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.