会员登陆 / 下载中心
当前位置:产品目录 > 抗体 >> 多克隆抗体
GALR2 antibody, 甘丙肽受体2抗体

 
编 号 PR-3975
产品名称 GALR2 antibody, 甘丙肽受体2抗体
规 格 0.2ml
价 格 1980元
应 用 IHC,WB,ELISA,ICC,IP,IF
品 牌 Hopebiot

详细信息: 说明书下载

Background: Receptor for the hormone galanin and for GALP. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)). The 387 amino acid protein galanin receptor-2 (GALR2) protein belongs to a family of G protein-coupled receptors that specifically bind galanin, a neuropeptide distributed throughout the central and peripheral nervous system, the pituitary gland, the gastrointestinal tract and in the endocrine and exocrine pancreas. GALR2 mRNA is abundant in parvocellular paraventricular nuclei, but in contrast to GALR1, is not expressed in magnocellular neurons or in supraoptic nuclei. Like GALR1 mRNA, GALR2 mRNA is expressed in the POMC neurons, dorsomedial nucleus, arcuate nucleus and in restricted peripheral tissue, with highest mRNA levels in human small intestine. Galanin-like peptide (GALP) is a putative endogenous ligand for GALR2. Binding of GALP to GALR2 results in increased GTPgS binding to the membrane-bound GALR2. GALR2 is therefore a receptor that mediates important functions of galanin in the hypothalamic-pituitary axis, plays a role in hippocampal and cerebellar function and mediates jejunal contraction.

Description: Rabbit polyclonal to GALR2

Immunogen: KLH conjugated synthetic peptide derived from GALR2

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 42 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;        

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.

相关同类产品:

网站首页 | 公司动态 | 产品中心 | 定制服务 | 代理产品 | 技术专栏 | 客户留言 | 联系我们

Copyright @ 2011 All Rights Reserved 江苏镇江厚普生物科技有限公司 备案/许可证编号为:苏ICP备11043267号

地址:江苏省丹阳市吕城工业园 邮编:212300 电子邮箱:hopebiotech@163.com

订货电话:0511-86909515 传真:0511-86909515 访问量:21581954