Background: Fibronectins are multi-domain glycoproteins that bind to a variety of substances including collagen, actin, heparin, DNA, fibrin and fibronectin receptors. Fibronectins are involved in a diverse array of important functions such as blood coagulation, wound healing, cell adhesion, cell differentiation and migration. Fibronectin type-III domain containing proteins, such as cell surface receptors and cell adhesion molecules, mediate protein-protein interactions and are involved in multiple biological processes including tissue development and metastasis. FNDC8 (fibronectin type III domain containing 8) is a 324 amino acid protein containing one fibronectin type-III domain. Conserved in human, chimpanzee, canine, bovine, mouse and rat, FNDC8 is encoded by a gene located on human chromosome 17q12. Human chromosome 17 comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1.

Description: Rabbit polyclonal to FNDC8

Immunogen: KLH conjugated synthetic peptide derived from FNDC8

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 36 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.