Background: BRD1 (Bromodomain-containing protein 1, Peregrin-like protein) is a 1,058 amino acid protein that is encoded by the human gene BRD1 and shares homology to Peregrin, a protein thought to function as a transcription factor. BRD1, like Peregrin, is a nuclear protein that contains one bromodomain, one PHD-type zinc finger and one PWWP domain. The zinc finger and leucine zipper domains of Peregrin and BRD1 have significant homology to those of AF-10 and MLLT6, two proteins that are involved in various acute leukemias. This suggests a possible role of BRD1 in the development of leukemia. Additionally, the chromosomal region (22q12-13) containing BRD1 may contain one or more susceptibility genes for schizophrenia (SZ) and bipolar affective disorder (BPD), implicating BRD1 in the pathogenesis of these mental illnesses.

Description: Rabbit polyclonal to BRD1

Immunogen: KLH conjugated synthetic peptide derived from BRD1

Specificity:  ·Reacts with Human, Mouse, Dog, Rabbit and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 137 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.