Background: The brain-expressed X-linked (Bex) family of proteins is expressed in the central nervous system, with highest levels detected in cerebellum, temporal lobe and pituitary tissues. Bex4, also known as Bex1-like 1, TCEAL7 or nerve growth factor receptor-associated protein 3, is a member of the Bex family involved in cell death regulation. It is expressed highly in heart, skeletal muscle and liver localizing to the nucleus and the cytoplasm. Bex4 is frequently downregulated or inactivated by methylation in ovarian tumors and cancer cell lines. Forced expression of Bex4 induces apoptosis and reduces colony formation. This suggests that Bex4 acts as a tumor suppressor. Bex4 shares 50% sequence homology with the apoptosis-inducing domain of Bex3 and 77% sequence homology with its regulatory domain. Bex4 is located on the X chromosome and is subject to X chromosome inactivation.

Description: Rabbit polyclonal to BEX4

Immunogen: KLH conjugated synthetic peptide derived from BEX4

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 14 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.