Background:  DOCK 8 (dedicator of cytokinesis 8) is a 2,099 amino acid protein that contains one DHR-2 (CZH-2) domain and one DHR-1 (CZH-1) domain. One of several members of the DOCK family of cytokinesis-regulating proteins, DOCK 8 functions as a potential guanine nucleotide exchange factor (GEF) that may play a role in protein activation and is thought to influence Actin organization. Defects in the gene encoding DOCK 8 may be associated with the pathogenesis of autosomal dominant mental retardation, possibly due to errors in Actin-based cytoskeletal structure. Multiple isoforms of DOCK 8 exist due to alternative splicing events. The gene encoding DOCK 8 maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome.

Description: Rabbit polyclonal to DOCK8

Immunogen: KLH conjugated synthetic peptide derived from DOCK8

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 190 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;

·Immunocytochemistry: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.