Background:  Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. VH1-related member Y (VHY) is a member of a subgroup of myristoylated VH1-like small dual specificity phosphatases. It is highly expressed in testis, specifically in pachytene spermatocytes (midstage of meiotic division I) and round spermatids. VHY localizes to the plasma membrane in transfected 293T or NIH/3T3 cells.

Description: Rabbit polyclonal to DUSP15

Immunogen: KLH conjugated synthetic peptide derived from DUSP15

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 32 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-200;

·Immunocytochemistry: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.