Background:  Apoptosis is defined as a set of cascades which, when initiated, programs the cell to undergo lethal changes such as membrane blebbing, mitochondrial break down and DNA fragmentation. Bcl-2 is one among many key regulators of apoptosis, which are essential for proper development, tissue homeostasis, and protection against foreign pathogens. Human Bcl-2 is an anti-apoptotic, membrane-associated oncoprotein that can promote cell survival through protein-protein interactions with other Bcl-2 related family members, such as the death suppressors Bcl-xl, Mcl-1, Bcl-w, and A1 or the death agonists Bax, Bak, Bik, Bad, and Bid. Bcl-2 protein family members form hetero- or homodimers that act as apoptotic regulators that are involved in a variety of cellular activities. BCL2L12, also known as BPR, is a 334 amino acid protein belonging to the Bcl-2 family. Expressed as two isoforms produced by alternative splicing, BCL2L12 is present in prostate, breast, small intestine, pancreas, thymus, colon and spinal chord.

Description: Rabbit polyclonal to BCL2L12

Immunogen: KLH conjugated synthetic peptide derived from BCL2L12

Specificity:  ·Reacts with Human, Mouse, Dog and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 37 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-200;

·Immunocytochemistry: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.