Background:  The anterior pituitary secretes a variety of hormones that are involved in cell growth, differentiation and development. Prolactin, a 226 amino acid protein, plays a role in multiple processes, including cell growth, reproduction and immune function. Full length prolactin, as well as an alternative splice product lacking the third exon, are secreted by endothelial cells involved in angiogenesis. In addition to its role in mammary development and lactation, prolactin is known to play a role in the development of mammary cancer, acting as both a mitogen and a differentiating agent. Prolactin has also been shown to enhance the proliferation of B cell hybridomas, leading to an overall increase in antibody production. Prolactin reverses the antiproliferative effects of the immunosuppressive cytokine TGF-beta. Prolactin is also associated with a variety of autoimmune diseases, including arthritis and type 1 diabetes. The receptor for Prolactin (PRL-R) belongs to the cytokine receptor superfamily. PRL-R is activated by ligand-induced homodimerization and subsequent cell signaling through the JAK/Stat pathway. The gene encoding human PRL-R maps to chromosome 5p13.2.

Description: Rabbit polyclonal to PRLR

Immunogen: KLH conjugated synthetic peptide derived from PRLR

Specificity:  ·Reacts with Human, Mouse, Pig and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 40 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-200;

·Immunocytochemistry: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.