Background:  Septins are members of a conserved family of cytoskeletal GTPases, specifically belonging to the large superclass of P loop GTPases. Septin proteins form homo- and hetero-oligomeric polymers that accumulate into higher-order filaments which may function as dynamic protein scaffolds. Septins play an important role in vesicle trafficking, apoptosis, cytoskeleton remodeling, infection, neurodegeneration, neoplasia and cytokinesis. Septin 12, also known as SEPT12, is a 358 amino acid cytoplasmic protein and filament-forming cytoskeletal GTPase that belongs to the Septin family. Widely expressed and existing as two alternatively spliced isoforms, Septin 12 expression levels are critical for mammalian spermiogenesis. Suggested to play a role in cytokinesis, Septin 12 can exist as a homodimer and interacts with both Septin 6 and Septin 11.

Description: Rabbit polyclonal to Septin 12

Immunogen: KLH conjugated synthetic peptide derived from Septin 12

Specificity:  ·Reacts with Human, Mouse, Dog and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 41 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-200;

·Immunocytochemistry: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.