Background: Clik1 (CLP36 interacting kinase), also known as STK35 (serine/threonine-protein kinase 35) or PDIK1 (PDLIM1-interacting kinase 1), is a 401 amino acid protein that belongs to the protein kinase superfamily. Localized predominately to the nucleus, Clik1 is expressed in the liver, kidney, pancreas, spleen, thymus, prostate and testis. However, coexpression with CLP36 causes relocalization of nuclear Clik1 to the cytoplasm and into actin stress fibers. Actin stress fibers form a dynamic organelle that is important in processes involving cell shape; such as cell migration, cell polarity and cytokinesis. It is suggested that Clik1 may be a novel regulator of the actomyosin cytoskeleton in nonmuscle cells.

Description: Rabbit polyclonal to STK35

Immunogen: KLH conjugated synthetic peptide derived from STK35

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 45 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.