Background:  Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. QIK (Qin-induced kinase) is a serine/threonine-protein kinase that belongs to the AMPK/SNF1 kinase family. Also designated SIK2 (SNF1-like kinase 2), QIK is one of twelve human kinases (NUAK1, NUAK2, BRSK1, BRSK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4 and MELK) related to AMPK. QIK is a ubiquitously expressed protein and is rapidly upregulated after a hormone-regulated form of Qin is activated. In vitro kinase tests demonstrate that QIK is capable of autophosphorylation. Elevated levels of QIK transcripts are also observed in Src-transformed cells, suggesting that Src and Qin share some targets.

Description: Rabbit polyclonal to SIK2

Immunogen: KLH conjugated synthetic peptide derived from SIK2

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 104 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.