Background:  CLN2, also known as Tripeptidyl peptidase I (TTP-I), a member of the family of serine-carboxyl proteinases (S53), plays a crucial role in lysosomal protein degradation, and a deficiency in this enzyme leads to fatal neurodegenerative disease. CLN2 is a lysosomal aminopeptidase that sequentially removes tripeptides from small polypeptides and also shows a minor endoprotease activity. In lysosomes, CLN2 proenzyme is converted into a mature enzyme with the assistance of another protease and is able to autoactivate in acidic pH in vitro via an unimolecular mechanism.

Description: Rabbit polyclonal to TPP1

Immunogen: KLH conjugated synthetic peptide derived from TPP1

Specificity:  ·Reacts with Human, Mouse, Dog and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 61 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.