Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes. Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice. Cloning of complementary DNAs encoding adiponectin receptors 1 (AdipoR1) has shown that AdipoR1 is abundantly expressed in skeletal muscle. This receptor is structurally and functionally distinct from G-protein-coupled receptors. Expression of AdipoR1 or suppression of AdipoR1 expression by small-interfering RNA supports our conclusion that they serve as receptors for globular and full-length adiponectin, and that they mediate increased AMP kinase and PPAR- ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectin. Widely expressed. Highly expressed in skeletal muscle. ADR 1 is expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes.
脂联素与受体结合后具有增强胰岛素敏感性，抗高血糖，抗动脉粥样硬化等生物学效应，任何增加或减少脂联素及其受体表达的方法都影响这些疾病的发生和发展。脂联素受体-1(AdipoR1和AdipoR2)同属于PAQR家族，具有七次跨膜蛋白的特有结构。
我公司新研发的AdipoR1(脂联素受体1)抗体已经通过检验测试，可以应用于蛋白印迹（WB），免疫组化（IHC），免疫细胞化学（ICC），酶联免疫吸附试验（ELISA），免疫沉淀（IP），免疫荧光（IF）实验。具体信息如下：
编号 产品名称
PR-1001， AdipoR1 Antibody
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镇江厚普生物科技有限公司销售部
2015-10-28