人类Ｔ淋巴细胞白血病病毒（HTLV-1）是导致人类淋巴细胞白血病、慢性脊髓瘫痪等慢性疾病的主要原因之一。Tax是HTLV-1编码的转录因子，尽管它不能直接结合到病毒基因的启动子即 5′长末端重复序列（LTR）上，但它的转录激活活性对于病毒复制是必需的。研究表明，宿主细胞的CREB可以与病毒基因组LTR上21bp的CRE样序列结合。CRE样的序列有3个，分别命名为结构域A、B、C。CREB结合于其中的结构域Ｂ。Tax可以通过相互作用与CBP（CREB binding protein）结合，并通过CBP将其携带到病毒基因组的启动子上。CREB-CBP-Tax复合物一旦形成，并结合到病毒基因启动子上，病毒基因便被激活开始转录和复制。HTLV-1 Tax蛋白与NF-κB活性调控蛋白相互作用表明HTLV-1 Tax蛋白通过促进HMGB1mRNA和蛋白的表达，进而激活NF-κB活性。
HTLV-1 causes two distinct human diseases, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T cell leukemia/lymphoma(ATL). The glycoproteins encoded by the env gene of HTLV-1 are essential for interaction with an unidentified receptor on the surface of target cells and play a crucial role in the infection process. Encoded by HTLV-1 Tax is a phospho-oncoprotein that functions as a transcriptional activator. Tax has the ability to modulate the expression and function of many cellular genes and has been crucial to understanding the HTLV-1-mediated transformation of cells. In activating cellular gene expression, Tax impinges upon several cellular signal-transduction pathways, including the CREB/ATF and NFκB pathways. In addition, Tax deregulates the expression of downstream genes, which mediate cell cycle control. The Tax protein of HTLV1 is an autoregulator of enhanced viral RNA transcription and it trans activates the viral 21 bp enhancer.
我公司新研发的磷酸化p-HTLV 1 Tax (Ser288)抗体已经通过检验测试，可以应用于蛋白印迹（WB），免疫组化（IHC），免疫细胞化学（ICC），酶联免疫吸附试验（ELISA），免疫沉淀（IP），免疫荧光（IF）实验。具体信息如下：
编号 产品名称
PR-1027P， p-HTLV 1 Tax (Ser288) antibody
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镇江厚普生物科技有限公司销售部
2013-07-10