Protein arginine methylation is an important posttranslational modification in eukaryotic cells, which has been implicated in RNA processing and trafficking, receptor mediated signaling, and transcription. PRMT4, also known as CARM1, catalyses the mono- and asymmetric dimethylation of arginine residues in several proteins involved in DNA packaging, transcription regulation and mRNA stability. PRMT4 methylates R2, R17 and R26 of histone H3 and cooperates synergistically with p300/CBP and p160 coactivators to enhance transcriptional activation by nuclear receptors. PRMT4 also methylates several non-histone proteins, including transcriptional coactivators such as p300/CBP, splicing factors and RNA binding proteins. PRMT4 is also a co-activator of p53, facilitating p53-mediated transcription through the methylation of histones H3 and H4.
我公司新研发的PRMT4(蛋白精胺酸N-甲基转移酶4)抗体以及配对磷酸化PRMT4(phospho S228)抗体已经通过检验测试,可以应用于蛋白印迹(WB),免疫组化(IHC),免疫细胞化学(ICC),酶联免疫吸附试验(ELISA),免疫沉淀(IP),免疫荧光(IF)实验。具体信息如下:
编号 产品名称
PR-1006, PRMT4 Antibody
PR-1006P, PRMT4 (phospho S228) Antibody
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镇江厚普生物科技有限公司销售部
2013-07-10