HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis.
我公司新研发的HMG-CoA reductase(3-羟-3-甲基戊二酰辅酶A还原酶)抗体以及配对磷酸化HMG-CoA reductase (pSer871)抗体已经通过检验测试,可以应用于蛋白印迹(WB),免疫组化(IHC),免疫细胞化学(ICC),酶联免疫吸附试验(ELISA),免疫沉淀(IP),免疫荧光(IF)实验。具体信息如下:
编号 产品名称
PR-1030, HMG-CoA reductase Antibody
PR-1030P, HMG-CoA reductase (pSer871) Antibody
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镇江厚普生物科技有限公司销售部
2013-07-10