Background:  HARE is the hyaluronan receptor for endocytosis, which mediates the endocytic clearance of hyaluronan (HA) and chondroitin sulfate from lymph fluid and blood. HARE is expressed in endothelial sinuses of liver, lymph nodes, spleen and bone marrow, and in specialized structures of the eye, heart, brain and kidney. Human and rat HARE each have two isoforms. HARE may serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. When studies of clearance of hyaluronan (HA) and scavenger receptor ligands by liver sinusoidal endothelial cells (LSECs) were performed, stabilin-2 had a clear scavenging profile, stabilin-1 did not.

Description: Rabbit polyclonal to Stabilin 2

Immunogen: KLH conjugated synthetic peptide derived from Stabilin 2

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 190 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.