Background:  Enzymes consisting of an HD domain are predicted to exhibit phosphohydrolase activity. These enzymes are suggested to participate in nucleic acid metabolism, signal transduction and possibly other functions in bacteria, archaea and eukaryotes. The HD domain consists of highly conserved residues, specifically histidines or aspartates. HDDC2 (HD domain-containing protein 2), also known as hepatitis C virus NS5A-transactivated protein 2, C6orf74, NS5ATP2 or CGI-130, is a 204 amino acid protein that contains one HD domain and belongs to the HDDC2 family. Existing as three alternatively spliced isoforms, the gene encoding HDDC2 maps to human chromosome 6q22.31. Making up nearly 6% of the human genome, chromosome 6 contains around 1,200 genes within 170 million base pairs of sequence. Porphyria cutanea tarda, Parkinson’s disease and Stickler syndrome have all been associated with genes located on chromosome 6.

Description: Rabbit polyclonal to HDDC2

Immunogen: KLH conjugated synthetic peptide derived from HDDC2

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 23 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.