Background:  Aspartoacylase-3 (ACY3), also known as aminoacylase-3, Aspartoacylase-2, acylase III or HCBP1 (Hepatitis C virus core-binding protein 1), is a 319 amino acid protein that deacetylates mercapturic acids in the proximal tubules of the kidney, where it is predominantly expressed. A member of the aspA/astE family and Aspartoacylase subfamily, Aspartoacylase-3 localizes to the cytoplasm of S2 and S3 proximal tubules and to the apical domain of S1 proximal tubules. Aspartoacylase-3 is also expressed at low levels in stomach, testis, heart, brain, lung and liver, and may function as an HCV (Hepatitis C virus) core binding protein. Aspartoacylase-3 is encoded by a gene that maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.

Description: Rabbit polyclonal to ACY3

Immunogen: KLH conjugated synthetic peptide derived from ACY3

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 35 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.