Background:  Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Isoform A does not seem to have a repressor activity. Isoform C does not seem to have a repressor activity. Ets-1 is the prototype member of a family of genes identified on the basis of homology to the v-Ets oncogene isolated from the E26 erythroblastosis virus. Members of the Ets gene family exhibit varied patterns of tissue expression and share a highly conserved carboxy terminal domain which contains a sequence related to the SV40 large T antigen nuclear localization sequence. This conserved carboxy domain is essential for Ets-1 binding to DNA and is likely to be responsible for the DNA binding activity of all members of the Ets gene family. TEL2, also known as ETV7 (ets variant gene 7), TREF or TELB, is a 341 amino acid nuclear protein that contains one PNT domain and one Ets DNA-binding domain. Expressed in hematopoietic tissue, TEL2 belongs to the Ets family and functions as a transcriptional repressor that binds to the DNA sequence 5'-CCGGAAGT-3'. Defects in the gene encoding TEL2 are associated with B-cell malignancies, suggesting an important role for TEL2 in carcinogenesis. Seven isoforms (designated A-G) of TEL2 exist due to alternative splicing events.

Description: Rabbit polyclonal to ETV7

Immunogen: KLH conjugated synthetic peptide derived from ETV7

Specificity:  ·Reacts with Human, Mouse, Pig, Dog and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 39 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.