Background:  The peptidyl-prolyl cis-/trans-isomerase (PPIase) superfamily consists of three subfamilies, all of which contain proteins that are involved in the transport, folding and assembly of proteins. Pin4 (Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4), also known as EPVH, PAR14 (Parvulin 14) or PAR17, is a 131 amino acid member of the parvulin family, one of the three PPIase subfamilies. Expressed throughout the body with lowest expression levels in neuronal tissue, Pin4 contains one PPIase domain and is thought to function as a helper protein that catalytically mediates protein folding events within the cell. Additionally, Pin4 is able to bind DNA and, via this binding, may be involved in regulation of both chromatin remodeling and the cell cycle.

Description: Rabbit polyclonal to PIN4

Immunogen: KLH conjugated synthetic peptide derived from PIN4

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 13 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.