Background:  Plastins (fimbrins) are members of a family of Actin-binding proteins that exhibit a tissue-specific expression pattern. Both L- and T-Plastin have been shown to be involved in cytoskeletal reorganization. L-Plastin, which is specifically expressed in hematopoietic cell lineages, has been proposed to be involved in the control of cell adhesion and motility. It is frequently expressed in cell lines derived from mammary solid tumors and is implicated in cancer invasion and metastasis. L-Plastin is also expressed in the majority of human cancer cell lines that are derived from various types of solid tumors. Additionally, L-Plastin is involved in regulating of leukocyte adhesion, and the phosphorylation of L-Plastin is implicated in modulating integrin regulation signaling pathways. T-Plastin is unique in that it is expressed in many types of tissues and notably absent in leukocytes.

Description: Rabbit polyclonal to Plastin L

Immunogen: KLH conjugated synthetic peptide derived from Plastin L

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 70 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.