Background:  Cyclic nucleotides are important intracellular second messengers which play important role variety of signal transduction process. The cyclic nucleotides are hydrolyzed and compartmentalized by a family of enzymes called phosphodieterases. Recently a new and distinct member (PDE11) of cyclic nucleotide family has been identified and cloned. The PDE11A exhibit 50% amino acid homology with the catalytic domain of the all other PDEs. The PDE11A resembles most to the PDE5 family members but has distinct biochemical properties than PDE5.

Description: Rabbit polyclonal to PDE11A3

Immunogen: KLH conjugated synthetic peptide derived from PDE11A3

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/200-500. Predicted Mol wt: 83 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-200;

·Immunocytochemistry: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.