Background:  PDE11A4 (Phosphodiesterase 11A isoform 4) is one of the four human isoforms of PDE11A and plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. It catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. The PDE11A gene undergoes tissue-specific alternative splicing that generates structurally and functionally distinct proteins.

Description: Rabbit polyclonal to PDE11A4

Immunogen: KLH conjugated synthetic peptide derived from PDE11A4

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/200-500. Predicted Mol wt: 113 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-200;

·Immunocytochemistry: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.