Background:  IL-1 (Interleukin-1) is a cytokine responsible for initiating a variety of activities through the activation of transcription factors, NFκB and AP-1, thereby promoting host response to injury or infection. The IL-1 superfamily is comprised of several ligands and receptors. IL-1F6, also known as interleukin-1 family member 6 (IL-1εF6) or interleukin-1ε(IL-1ε), is a secreted ligand belonging to this superfamily. IL-1F6 is expressed in a variety of tissues, including lymph node, spleen, thymus, leukocytes, tonsil, fetal brain and bone marrow. It exists as a nitroprotein, post-translationally modified with a nitro group on tyrosine residue 96. IL-1F6 activates the IL-1Rrp2 and IL-1RAcP-dependent pathway leading to NFκB activation. Similar to other family members, IL-1F6 can be regulated by bacterial lipopolysaccharide (LPS).

Description: Rabbit polyclonal to IL36 alpha

Immunogen: KLH conjugated synthetic peptide derived from IL36 alpha

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 18 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.